Direct N-alkylation of unprotected amino acids with alcohols

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Direct N-alkylation of unprotected amino acids with alcohols

N-alkyl amino acids find widespread application as highly valuable, renewable building blocks. However, traditional synthesis methodologies to obtain these suffer from serious limitations, providing a major challenge to develop sustainable alternatives. We report the first powerful catalytic strategy for the direct N-alkylation of unprotected α-amino acids with alcohols. This method is highly s...

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Efficient and chemoselective alkylation of amines/amino acids using alcohols as alkylating reagents under mild conditions.

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ژورنال

عنوان ژورنال: Science Advances

سال: 2017

ISSN: 2375-2548

DOI: 10.1126/sciadv.aao6494